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Monckeberg's arteriosclerosis
Mönckeberg's arteriosclerosis, or Mönckeberg's sclerosis, also called medial calcific sclerosis, is a form of arteriosclerosis or vessel hardening, where calcium deposits are found in the muscular middle layer of the walls of arteries (the tunica media). It is an example of dystrophic calcification.This condition occurs as an age related degenerative process.However it can happen in pseudoxanthomas elasticum and idiopathic arterial calcification of infancy like pathological condition also. Its clinical significance and etiology are not well understood and its relationship to atherosclerosis and other forms of vascular calcification are the subject of disagreement.
Mönckeberg's arteriosclerosis is named after Johann Georg Mönckeberg,〔J. G. Mönckeberg. Über die reine Mediaverkalkung der Extremitätenarterien und ihr Verhalten zur Arteriosklerose. Virchows Archiv für pathologische Anatomie und Physiologie, und für klinische Medicin, Berlin, 1903, 171: 141-167.〕 who first described it in 1903.
==Signs and symptoms==
Typically, Mönckeberg’s arteriosclerosis is not associated with symptoms unless complicated by atherosclerosis, calciphylaxis, or accompanied by some other disease. However presence of Mönckeberg’s arteriosclerosis is associated with poorer prognosis. This is probably due to vascular calcification causing increased arterial stiffness, increased pulse pressure and resulting in exaggerated damage to the heart and kidneys.
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